Polynucleotides vs Tear Trough Filler
Polynucleotides improve under-eye skin quality — hydration, texture, and fine lines — while tear trough filler restores lost volume and reduces structural shadowing. The right choice depends on what’s actually causing your concern, which is why a proper clinical assessment matters before any treatment.
If your concealer is doing a full shift every morning, you’re not alone. The under-eye area is one of the first places to show signs of tiredness, ageing, and general life — and it can be stubborn to treat. Two treatments come up time and again in this conversation: polynucleotides and tear trough filler. Both work beautifully in the right circumstances. The problem is, they do very different things.
In this guide, we’ll break down exactly what each treatment does, who it suits, and how to tell which one — or which combination — might be right for you. And if you’d rather just talk it through, we offer a free consultation at our South Woodford clinic. No obligation, just honest advice.
Why the under-eye area is so tricky (and why guesswork isn’t ideal)
The skin beneath your eyes is around 0.5mm thick — roughly the same as a piece of paper. It’s delicate, highly vascular, and prone to swelling. It’s also one of the most emotionally loaded areas of the face, because it’s where “tired” tends to live, even when you’ve had a full eight hours.
Here’s the thing: “dark circles” aren’t one single problem. They can be caused by:
- Pigmentation — often genetic, and can appear from a young age
- Structural hollowing — the shadow cast by a sunken tear trough as volume decreases with age
- Vascular visibility — thin skin allowing underlying blood vessels to show through
- Puffiness or fluid retention — which creates a different kind of shadow beneath the eye
Often it’s a combination. That’s why the same treatment doesn’t work for everyone, and why a proper assessment is worth its weight in gold before you book anything.
What are polynucleotides (and what does “salmon DNA” actually mean)?

You might have seen the phrase “salmon DNA under eyes” doing the rounds on social media and wondered what on earth that means. Fair question. Polynucleotides — sometimes referred to as PDRN — are long-chain DNA molecules derived from purified salmon or trout DNA. Before you picture anything alarming: the DNA is extensively purified, biocompatible, and has been used safely in medical and aesthetic applications for years.
When injected into the skin, polynucleotides don’t add volume. Instead, they stimulate your skin’s own repair processes — specifically, they activate fibroblasts, the cells responsible for producing collagen and elastin. The result, over a course of treatments, is skin that looks healthier, more hydrated, and more resilient from within.
For the under-eye area specifically, polynucleotide treatment can help with:
- Fine lines and crepey texture
- Thinning, fragile skin
- Dark circles linked to poor skin quality or vascular visibility
- Dullness and overall lack of brightness
What polynucleotides won’t do is replace lost volume. If your main concern is a deep hollow causing structural shadowing, polynucleotides alone are unlikely to resolve it. This is an important distinction — and one we’ll always cover clearly at your consultation.
A typical course involves around three to four sessions, spaced two to four weeks apart. Most people notice initial improvements in hydration and texture within the first one to two weeks, with fuller results developing over two to three months. Results generally last six to nine months, with maintenance sessions recommended annually.
What is tear trough filler?

Tear trough filler uses hyaluronic acid — a substance naturally found in the body — to restore lost volume in the groove between the lower eyelid and upper cheek. As we age, this hollow deepens and casts a shadow that makes the eyes look sunken, tired, or older than they are.
By carefully placing filler along this groove, the hollow softens, the shadow reduces, and the overall area looks brighter and more rested. Results are often visible almost immediately, with full settling over around two weeks. Most people find results last between six and twelve months, depending on the product used and individual metabolism.
The critical word here is carefully. The under-eye area is one of the highest-risk zones for filler treatment, precisely because of that thin skin and complex blood vessel anatomy. Technique, product choice, and thorough assessment are non-negotiable. We only treat clients we believe are good candidates — not every under-eye concern is suitable for filler, and honest clinical advice matters far more than a quick booking.
Polynucleotides vs tear trough filler: the quick comparison
| Polynucleotides | Tear trough filler | |
| Best for | Skin quality, texture, fine lines, hydration | Volume loss, structural hollowing, tear trough shadows |
| Result timeline | Gradual — 2 to 12 weeks | Often visible quickly; settled at ~2 weeks |
| Longevity | 6 to 9 months typically | 6 to 12 months typically |
| Sessions needed | Course of 3 to 4, then maintenance | Usually 1 session, with top-ups as needed |
| Downtime | Minimal — mild redness or small bumps, same-day return | Mild swelling and possible bruising; settles within days |
| Key risks | Very low; biocompatible and well-tolerated | Swelling, Tyndall effect, migration, vascular risks (rare but serious) |
| Reversible? | Not reversible, but biocompatible and naturally absorbed | Yes — hyaluronic acid filler can be dissolved |
Not sure which column sounds more like your concern? We can talk through that at your free consultation.
Which one is right for your under-eye concern?
If you have hollows or a visible tear trough shadow
Tear trough filler is likely the stronger option — provided you’re a suitable candidate. Volume loss is the root cause here, and polynucleotides won’t address structural depth in the same way.
If your skin looks crepey, thin, or lined
Polynucleotides are often the better starting point. The skin quality itself is the issue, and regenerative treatment targets exactly that.
If you have dark circles
It depends on the cause. Shadow from hollowing? Filler may help significantly. Vascular visibility or skin thinning? Polynucleotides under eyes may improve brightness over time. Pigment-based circles? Neither treatment is a full solution, and managing expectations is part of honest advice.
If you’re prone to puffiness or fluid retention
Tear trough filler may not be ideal. Hyaluronic acid attracts water, which can worsen puffiness in clients who are already prone to it. Polynucleotides are typically the safer route here.
If you’re a first-timer wanting subtle, natural change
Polynucleotides offer a lower-risk entry point with gradual, natural-looking improvement. They’re a great starting treatment for the under-eye area.
If you’re interested in combining both
In some cases, a staged approach works brilliantly — improving skin quality first with polynucleotides, then addressing any residual hollowing with filler once the tissue is in better condition. That said, not everyone needs both, and we’ll only ever recommend what’s genuinely right for your anatomy.
Can you combine polynucleotides and tear trough filler?
Yes — and for some clients, a combined approach gives the best result. Polynucleotide treatment can improve the quality and resilience of the skin before filler is introduced, which may support a more natural outcome and reduce the risk of issues like swelling or poor integration.
That said, combining treatments isn’t always necessary or appropriate. Sometimes one is clearly the right choice and the other would add nothing useful. At our clinic, we’re big believers in the minimum effective approach — we’ll never recommend more than your skin actually needs.
What to expect at our South Woodford clinic

At Nurse Hannah Clinic, every under-eye treatment begins with a proper consultation. We’ll assess your skin quality, under-eye anatomy, swelling tendencies, and what’s actually causing the concern — before recommending anything.
We offer both polynucleotide treatment in South Woodford and tear trough filler as part of our facial aesthetics range, and we’re experienced in treating clients from across East London and beyond, including Leytonstone, Wanstead, Snaresbrook, and Woodford Green.
Our clinic is designed to feel like a calm, comfortable space — somewhere you can ask questions, change your mind, and leave feeling genuinely looked after. No hard sell. No rushed appointments. Just honest advice and, where appropriate, outstanding results that look effortlessly like you.
Book a free consultation online or call us.
Frequently asked questions
Are polynucleotides good for under eyes?
Yes, particularly for improving skin quality. Polynucleotides can help with fine lines, crepey texture, thin skin, and brightness in the under-eye area. They’re well-tolerated, biocompatible, and well-suited to this delicate zone.
Is “salmon DNA” under-eye treatment safe?
Yes. The term refers to PDRN — polynucleotides derived from purified salmon DNA. Despite the name, the product undergoes extensive purification and is highly biocompatible. It’s been used in medical applications for many years and has a strong safety profile.
Do polynucleotides help dark circles?
They can, depending on what’s causing them. If dark circles stem from skin thinning, poor hydration, or visible blood vessels beneath delicate skin, polynucleotides may help improve brightness over time. If the cause is structural shadowing from hollowing, filler is typically more appropriate. Pigment-based circles are harder to treat with either.
How long do polynucleotides take to work under the eyes?
Most people notice early improvements in hydration and skin texture within one to two weeks. More significant changes — firmer, smoother, more even skin — tend to become visible over two to three months as collagen production builds. A course of three to four sessions is typically recommended.
Is tear trough filler safe?
Yes, when performed by a qualified medical professional using the correct products and technique. The under-eye area is considered a higher-risk zone due to its thin skin and vascular anatomy, which is why practitioner experience and proper patient selection are essential.
What are the risks of tear trough filler?
Common, temporary side effects include mild swelling and bruising. Less common but possible risks include the Tyndall effect (a bluish tint caused by filler placed too superficially), filler migration, and — in very rare cases — vascular occlusion. Using a cannula technique and choosing the right filler significantly reduces these risks. HA fillers can be dissolved if needed.
Will tear trough filler make my under eyes look puffy?
It can in the wrong candidate. Clients who are prone to fluid retention, have very thin skin, or have eye bags caused by fat prolapse rather than volume loss may find filler worsens the appearance. A proper assessment helps identify whether you’re a suitable candidate before any treatment takes place.
Which is better for hollows: polynucleotides or tear trough filler?
For structural hollowing and tear trough shadows, filler is typically the more effective option. Polynucleotides improve skin quality but don’t replace volume in the same way. That said, suitability matters — not everyone with hollows is automatically a good filler candidate.
Can you have both polynucleotides and tear trough filler?
Yes, and for some clients a combined approach gives excellent results. A common approach is to use polynucleotides to improve skin quality first, then introduce filler once the tissue is in better condition. We’ll always advise on whether a combined plan genuinely makes sense for you.
How do I know which under-eye treatment I need?
The honest answer is: an in-person assessment. The under-eye area has multiple possible causes for the same appearance, and choosing the right treatment depends on your anatomy, skin quality, swelling tendency, and what’s actually driving the concern. That’s exactly what our free consultation is for.
Final thoughts: stop guessing, start with a proper plan
To sum it up simply: polynucleotides improve skin quality, filler restores volume. One isn’t better than the other — they solve different problems. The most important step is figuring out which problem you actually have.
If your under-eyes are making you look more “early Monday morning” than you feel, let’s sort that out properly. Book a free consultation at Nurse Hannah Clinic in South Woodford and we’ll talk through the safest, most natural-looking option for you — whether that’s polynucleotides, tear trough filler, or a staged combination of both.
Book your free consultation — or call us. We’re welcoming clients from South Woodford, Leytonstone, Snaresbrook, Wanstead, and across East London.




















